Docosanol INN 100mg/gm (10%): cream
Mode of action: Docosanol is a 22-carbon, straight chain saturated alcohol that works by inhibiting fusion between the human cell plasma membrane and the herpes simplex virus envelope, thereby preventing viral entry into the cells and subsequent viral replication.
Ind: Treatment of acute and recurrent oral-facial herpes simplex episodes (herpes labialis or cold sores or fever blisters).
C/I: Hypersensitivity to docosanol or any othercomponents of the formulation.
S/E: Generally docosanol is well tolerated. Rarely burning, dryness of skin, itching, rash, swelling & headache are seen after administration of docosanol.
Precautions: 1. Cream should only be applied to the lips and face. Avoid application in or near the eyes. Emphasize hand washing following application.
Do not touch the lesion to prevent spread to others or to other parts of the body. 2. Herpes infection is a recurring disease. Viral reactivation may be triggered by ultraviolet radiation or sun exposure, stress, fatigue chilling. Other possible triggers include fever, injury, menstruation dental work and infectious diseases (cold, flu). 3.
Patients are advised to notify health care professionals if lesions do not heal in 14 days, or if fever, rash or swollen lymph nodes occur. Pregnancy & lactation: There are no adequate and well-controlled studies in pregnant women. However, this medicine has not been shown to cause any birth defects or other problems in animal studies using rats or rabbits. It is also not known whether docosanol is excreted in breast milk or not. Therefore, consideration should be given to discontinue nursing temporarily or
withhold the drug while the mother is nursing.
Dosage & admin: Adults and children of 12 years of age and older: Apply 5 times a day until healed. Treatment should be started at earliest signs or symptoms of herpes infection (blisters, open sores, pain in the infected area, itching, burning tingling or numbness).
Drug inter: There are no known drug interactions with docosanol.
5gm tube: 50.00 MRP
