Sofosbuvir

Sofosbuvir is a hepatitis C virus (HCV) nucleotide analog NS5B polymerase inhibitor indicated for the treatment of chronic hepatitis C (CHC) infection as a component of a combination antiviral treatment regimen.

Sofosbuvir efficacy has been established in subjects with HCV genotype 1, 2, 3 or 4 infection, including those with hepatocellular carcinoma meeting Milan criteria (awaiting liver transplantation) and those with HCV/HIV-1 co-infection.

The following points should be considered when initiating treatment with Sofosbuvir:

• Monotherapy of Sofosbuvir is not recommended for treatment of CHC.
• Treatment regimen and duration are dependent on both viral genotype and patient population.
• Treatment response varies based on baseline host and viral factor.